What is venlafaxine?
Venlafaxine is used in adults to treat major depressive disorder. Venlafaxine extended-release (long-acting) capsules are also used to treat generalized anxiety disorder (GAD; excessive worrying that is difficult to control), social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life), and panic disorder (sudden, unexpected attacks of extreme fear and worry about these attacks).
Venlafaxine belongs to in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). Venlafaxine works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance.
Warnings
You should not take venlafaxine if you have uncontrolled narrow-angle glaucoma.
Do not use venlafaxine within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor, such as: mood or behavioral changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Do not stop using venlafaxine without first talking to your doctor.
Do not give this medicine to anyone younger than 18 years old without the advice of a doctor. Venlafaxine is not FDA approved for use in children.
Related/similar drugs
Trintellix, Vraylar, gabapentin, acetaminophen, sertraline, trazodone, escitalopram
Before taking this medicine
You should not take venlafaxine if you are allergic to it or to desvenlafaxine (Pristiq).
Do not use venlafaxine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine.
Tell your doctor if you also use stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with venlafaxine could cause a serious condition called serotonin syndrome.
To make sure venlafaxine is safe for you, tell your doctor if you have ever had:
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- bipolar disorder (manic depression);
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- heart disease, high blood pressure, high cholesterol or triglycerides;
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- diabetes;
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- lung disease;
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- a thyroid disorder;
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- a seizure;
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- sexual problems;
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- bleeding problems;
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- low blood levels of sodium; or
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- liver or kidney disease.
Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.
Taking this medicine during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop venlafaxine without asking your doctor.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of venlafaxine on the baby.
Ask a doctor if it is safe to breastfeed while using this medicine.
Venlafaxine pregnancy and breastfeeding warnings (more detail)
How should I take venlafaxine?
Take venlafaxine as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
Take with food at the same time each day.
Swallow the extended-release capsule or tablet whole and do not crush, chew, break, or open it.
If you cannot swallow a capsule whole, open it and mix the medicine with applesauce. Swallow the mixture right away without chewing.
Tell your doctor if you have any changes in sexual function, such as loss of interest in sex, trouble having an orgasm, or (in men) problems with erections or ejaculation. Some sexual problems can be treated.
Your symptoms may not improve for up to several weeks. Do not stop using venlafaxine suddenly, or you could have unpleasant symptoms (such as agitation, confusion, tingling or electric shock feelings). Ask your doctor before stopping the medicine.
Your blood pressure will need to be checked often.
This medicine may cause false results on a drug-screening urine test. Tell the laboratory staff that you use venlafaxine.
Store at room temperature away from moisture and heat.
Dosing Information
Usual Adult Dose for Depression:
Immediate release:
-Initial dose: 37.5 mg orally twice a day OR 25 mg orally 3 times a day
-Maintenance dose: 75 to 150 mg orally per day, given in divided doses
-Maximum dose:
—Moderately depressed outpatients: 225 mg/day
—Severely depressed inpatients: 375 mg/day
Extended release:
-Initial dose: 75 mg orally once a day
-Maintenance dose: 75 to 225 mg orally once a day
-Maximum dose:
—Moderately depressed outpatients: 225 mg/day
—Severely depressed inpatients: 375 mg/day
Comments:
-The daily dosage of immediate-release formulations may be divided into 2 or 3 doses/day.
-Healthcare providers should consider initial extended release doses of 37.5 mg orally once a day for 4 to 7 days (before increasing the dose to 75 mg/day) in patients who may require additional time to adjust to the drug.
-Doses may be increased in daily increments of up to 75 mg orally at intervals of no less than 4 days.
-Patients should be periodically reassessed for the continued need of maintenance treatment and for the appropriate dose of treatment.
-Use of doses exceeding 225 mg/day is limited.
Usual Adult Dose for Generalized Anxiety Disorder:
Extended release:
-Initial dose: 75 mg orally once a day
-Maintenance dose: 75 to 225 mg orally once a day
-Maximum dose: 225 mg/day
Comments:
-Healthcare providers should consider initial extended release doses of 37.5 mg orally once a day for 4 to 7 days (before increasing the dose to 75 mg/day) in patients who may require additional time to adjust to the drug.
-Doses may be increased in daily increments of up to 75 mg orally at intervals of no less than 4 days.
Usual Adult Dose for Social Anxiety Disorder:
Extended release: 75 mg orally once a day
Comment: There is no evidence that doses greater than 75 mg/day confer additional benefit.
Usual Adult Dose for Panic Disorder:
Extended release:
-Initial dose: 37.5 mg orally once a day for 7 days, then 75 mg orally once a day thereafter
-Maintenance dose: 75 to 225 mg orally once a day
-Maximum dose: 225 mg/day
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